A unified Bayesian inversion approach for a class of tumor growth models with different pressure laws

¹ Beijing International Center for Mathematical Research, Peking University, No. 5 Yiheyuan Road, Haidian District, Beijing 100871, P.R. China
² Department of Mathematics, The Chinese University of Hong Kong, Lady Shaw Building, Ma Liu Shui, Hong Kong, P.R. China

^* Corresponding author: zhennan@bicmr.pku.edu.cn

Received: 26 August 2023
Accepted: 4 February 2024

Abstract

In this paper, we use the Bayesian inversion approach to study the data assimilation problem for a family of tumor growth models described by porous-medium type equations. The models contain uncertain parameters and are indexed by a physical parameter m, which characterizes the constitutive relation between density and pressure. Based on these models, we employ the Bayesian inversion framework to infer parametric and nonparametric unknowns that affect tumor growth from noisy observations of tumor cell density. We establish the well-posedness and the stability theories for the Bayesian inversion problem and further prove the convergence of the posterior distribution in the so-called incompressible limit, m → ∞. Since the posterior distribution across the index regime m ∈ [2, ∞) can thus be treated in a unified manner, such theoretical results also guide the design of the numerical inference for the unknown. We propose a generic computational framework for such inverse problems, which consists of a typical sampling algorithm and an asymptotic preserving solver for the forward problem. With extensive numerical tests, we demonstrate that the proposed method achieves satisfactory accuracy in the Bayesian inference of the tumor growth models, which is uniform with respect to the constitutive relation.